Ancient chicken remains reveal the origins of virulence in Marek’s disease
Idioma: Anglès Matèria/es: Recursos en línia: A: Science Vol 382, Issue 6676 (14 Dec. 2023) pp. 1276-1281Resum: Marek’s disease virus (MDV) causes tumors in chickens and has increased in virulence over the past century. Fiddaman et al. studied ancient DNA from chickens to reveal the evolutionary history of this once mild disease (see the Perspective by Duchene). They sequenced MDV DNA from 15 ancient chickens, finding that these strains were basal to modern ones and identifying multiple fixed genetic changes. Testing the ancient version of the gene Meq, a regulator of tumor formation, the authors found that virulence was greatly reduced compared with modern versions. These results shed light on the evolution of virulence in a major disease in modern agriculture.| Tipus d'ítem | Biblioteca actual | Biblioteca d'origen | Col·lecció | Signatura topogràfica | Materials especificats: | URL | Estat | Data de venciment | Codi de barres | |
|---|---|---|---|---|---|---|---|---|---|---|
| Article | Centre de Documentació del Parc Natural del Montseny. Secció Humanitats | Centre de Documentació del Parc Natural del Montseny. Secció Humanitats | Digital | Accés lliure | Disponible | CDMSY-ARB23120018 |
Marek’s disease virus (MDV) causes tumors in chickens and has increased in virulence over the past century. Fiddaman et al. studied ancient DNA from chickens to reveal the evolutionary history of this once mild disease (see the Perspective by Duchene). They sequenced MDV DNA from 15 ancient chickens, finding that these strains were basal to modern ones and identifying multiple fixed genetic changes. Testing the ancient version of the gene Meq, a regulator of tumor formation, the authors found that virulence was greatly reduced compared with modern versions. These results shed light on the evolution of virulence in a major disease in modern agriculture.
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